3,5-Difluorophenol → HCID 18759999, compound

HRID 432627Notes

Reaction equation

HRID 432627 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[F:24][C:25]1[CH:26]=[C:27]([OH:32])[CH:28]=[C:29]([F:31])[CH:30]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([O:32][C:27]3[CH:26]=[C:25]([F:24])[CH:30]=[C:29]([F:31])[CH:28]=3)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 759283,5-DifluorophenolHCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazine

Product 1

HCID 18759999HCID 18759999, compound

Procedure

In a similar manner as in Example 2, 3,4-bis(4-methoxyphenyl)-6-chloropyridazine (250 mg, 0.766 mmol) and 3,5-difluorophenol were reacted as starting materials at 150° C. for 6 hours and post-treatment was then conducted, whereby the title compound was obtained as colorless needles (315.0 mg, 98.0%). Melting point: 135.1-137.5° C. (ethyl acetate-diethyl ether-hexane).

Workup

  1. customat 150° C.
  2. customfor 6 hours

Sources & evidence

ORD record
ord-cec5920df4464ed19d3d84fdd99d1784
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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