2,4-Difluorophenol → HCID 10293754, compound

HRID 432642Notes

Reaction equation

HRID 432642 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:3]=1.[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1[OH:30]>>[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1[O:30][C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 1230512,4-DifluorophenolHCID 18760041HCID 18760041, compound

Product 1

HCID 10293754HCID 10293754, compound

Procedure

In a similar manner as in Example 2, 6-chloro-3-(4-methoxyphenyl)-4-phenylpyridazine (215 mg, 0.725 mmol) and 2,4-difluorophenol were reacted as starting materials at 150° C. for 20 hours and post-treatment was then conducted, whereby the title compound was obtained as colorless needles (169.7 mg, 60.0%). Melting point: 169.0-169.9° C. (ethyl acetate-hexane).

Workup

  1. customat 150° C.
  2. customfor 20 hours

Sources & evidence

ORD record
ord-38a57d90151b436fa433c68384c5dbf9
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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