2,4-Difluorophenol → HCID 18759992, compound

HRID 432649Notes

Reaction equation

HRID 432649 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]3[O:14][CH2:15][CH2:16][O:17][C:10]=3[CH:9]=2)=[C:4]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[CH:3]=1.[F:26][C:27]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=1[OH:34]>>[F:26][C:27]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=1[O:34][C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]3[O:14][CH2:15][CH2:16][O:17][C:10]=3[CH:9]=2)=[C:4]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 1230512,4-DifluorophenolHCID 18760038HCID 18760038, compound

Product 1

HCID 18759992HCID 18759992, compound

Procedure

In a similar manner as in Example 2, 6-chloro-3-(3,4-ethylenedioxyphenyl)-4-(4-methoxyphenyl)pyridazine (136 mg, 0.383 mmol) and 2,4-difluorophenol were reacted as starting materials at 120° C. for 8 hours and post-treatment was then conducted, whereby the title compound was obtained as colorless prisms (113 mg, 65.7%). Melting point: 158.0-159.5° C. (ethyl acetate-hexane).

Workup

  1. customat 120° C.
  2. customfor 8 hours

Sources & evidence

ORD record
ord-c62810bed21f4c5ea976e77d1ff911c6
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

Loading…