Picolyl chloride hydrochloride → HCID 18760189, compound

HRID 432686Notes

Reaction equation

HRID 432686 reaction equation
[O:1]([C:8]1[C:17]2[N:18]=[CH:19][N:20]([CH2:21][CH2:22][OH:23])[C:16]=2[C:15]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[N:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH2:31]Cl>>[O:1]([C:8]1[C:17]2[N:18]=[CH:19][N:20]([CH2:21][CH2:22][O:23][CH2:31][C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][N:25]=3)[C:16]=2[C:15]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 23392Picolyl chloride hydrochlorideHCID 18760167HCID 18760167, compound

Product 1

HCID 18760189HCID 18760189, compoundYield 55.6%

Procedure

Using the general method of Example 13 Part F, 2-(4-phenoxy-1H-imidazo[4,5-c]quinolin-1-yl)ethanol (0.9 g, 2.95 mmol) was reacted with 2-picolyl chloride hydrogen chloride (0.53 g, 3.24 mmol) and the product purified to provide 0.65 g of 4-phenoxy-1-[2-(pyridin-2-ylmethoxy)ethyl]-1H-imidazo[4,5-c]quinoline.

Workup

  1. customthe product purified

Sources & evidence

ORD record
ord-60e5d5e69b414f44b0f8a62575101d28
Source dataset
uspto-grants-2003_12
Patent number
US06664260B2

Reaction notes

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