2-Iodothiophene → HCID 18760182, compound

Participants

Reaction Steps

Using the general method of Example 3 Part A, 4-phenoxy-1-[2-(prop-2-ynyloxy)ethyl]-1H-imidazo[4,5-c]quinoline (10 g, 29.4 mmol) was reacted with 2-iodothiophene (3.6 mL, 32.3 mmol). The glassy solid obtained from purification by chromatography over silica gel (98/2 dichloromethane/methanol) was triturated with ether to provide 5.3 g of 4-phenoxy-1-{2-[(3-thien-3-ylprop-2-ynyl)oxy]ethyl}-1H-imidazo[4,5-c]quinoline as a gray powder.

Provenance & Evidence