反应详情

温度

52.5 °C

Tetrazolo[1,5-a]quinolin-5-ol (63.25 g, 0.34 mol) was added to glacial acetic acid (630 ml) to form a thick off white suspension. The mixture was vigorously stirred while nitric acid (23.6 ml, 0.37 mol, 70% solution) was slowly added. The reaction was then heated from 25 to 80° C. over a period of 15 minutes. A yellow precipitate formed and the reaction was maintained at 80° C. for 5 minutes. The mixture was slowly cooled to 0° C. The solid was collected by filtration and then dried in vacuo to yield 60.0 g of 4-nitro-tetrazolo[1,5-a]quinolin-5-ol as a yellow solid.

1. customto form a thick off white suspension
2. additionwas slowly added
3. customA yellow precipitate formed
4. temperaturethe reaction was maintained at 80° C. for 5 minutes
5. temperatureThe mixture was slowly cooled to 0° C
6. filtrationThe solid was collected by filtration
7. customdried in vacuo