Ethanol → HCID 68698807, compound

HRID 432786Notes

Reaction equation

HRID 432786 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH2:10]([OH:12])[CH3:11].[CH2:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][C:14]1=O.[OH-].[Na+]>O>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[C:11]1[C:17]2[C:16](=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:15](=[CH:14][C:13]2[CH:8]=[CH:7][CH:6]=[CH:3][C:2]=2[F:1])[C:10]1=[O:12]

Participants

6

Reactant 4

HCID 702Ethanol2×HCID 119832-IndanoneHCID 14798Sodium HydroxideHCID 67970o-Fluorobenzaldehyde

Product 1

HCID 68698807HCID 68698807, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 1.88 g (15.13 mmol) of 2-fluorobenzaldehyde in 3.0 mL of abs. ethanol was added over a period of 5 min to a solution containing 1.00 g (7.57 mmol) of 2-indanone and 90 mg (2.27 mmol) of NaOH in 40 mL of a 1:1 mixture of abs. ethanol and water at room temperature. The mixture was allowed to stir for 12 hrs and solids formed were collected by suction filtration and washed with cold ethanol and dried under high vacuum.

Workup

  1. additionin 40 mL of a 1:1 mixture of abs
  2. customat room temperature
  3. customsolids formed
  4. filtrationwere collected by suction filtration
  5. washwashed with cold ethanol
  6. customdried under high vacuum

Sources & evidence

ORD record
ord-183b624204dc49cf8c3c9b8e2ba09c88
Source dataset
uspto-grants-2003_12
Patent number
US06664272B2

Reaction notes

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