HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiophenecarbonyl chloride → Ethyl 1-(2-thienylcarbonyl)-3-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiophenecarbonyl chloride | HCID 78928 | — |
| Reactant | Ethyl nipecotate | HCID 98969 | — |
| Reactant | Ethyl 1-benzoyl-3-piperidinecarboxylate | HCID 3784394 | — |
| Product | Ethyl 1-(2-thienylcarbonyl)-3-piperidinecarboxylate | HCID 2904303 | — |
Reaction Steps
The reaction was run in the same manner as ethyl 1-benzoyl-3-piperidinecarboxylate, starting with ethyl nipecotate (202.9 mg; 1.29 mmol) and commercially available 2-thiophenecarbonyl chloride (138 μl; 1.29 mmol). The crude product was distilled at 225° C./0.1 torr, giving ethyl (2-thiophenecarbonyl)-3-piperidinecarboxylate (249.8 mg) as a yellow oil. MS m/z (positive ion) 290 (M+Na+; 40), 268 (MH+; 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06664271B1 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-af32ce0ff436400f9149418448792eb6 |
| Source note | uspto-grants-2003_12 |