HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Fluorobenzoyl chloride → Ethyl 1-(4-fluorobenzoyl)4-oxo-3-piperidinecarboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 3-Piperidinecarboxylic acid, 4-oxo-, ethyl ester, hydrochloride (1:1) | HCID 107315 | — |
| Edukt | Ethyl 1-benzoyl-3-piperidinecarboxylate | HCID 3784394 | — |
| Produkt | Ethyl 1-(4-fluorobenzoyl)4-oxo-3-piperidinecarboxylate | HCID 18760280 | 84,4% |
Reaktionsschritte
The reaction was run in the same manner as ethyl 1-benzoyl-3-piperidinecarboxylate, starting with ethyl 4-piperidone-3-carboxylate hydrochloride (200.4 mg; 0.97 mmol), diisopropylethylamine (360 μl; 2.08 mmol) and 4-fluorobenzoyl chloride (114 μl; 0.97 mmol), giving ethyl 1-(4-fluorobenzoyl)4-oxo-3-piperidinecarboxylate (240.2 mg) as a thick, light yellow oil without further purification. MS m/z (positive ion) 348 (25), 316 (M+Na+; 75), 294 (MH+; 100).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06664271B1 |
| Quelldatensatz | uspto-grants-2003_12 |
| ORD ID | ord-57f9c69405f244af901f89025cb777ef |
| Quellennotiz | uspto-grants-2003_12 |