反应详情

To a suspension of 2-chloro-3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)pyrimidine (1.07 g) in ethanol (10 ml) was added piperazine (0.70 g). The mixture was refluxed for 3 hours, cooled to ambient temperature. The mixture was evaporated, and the residue was dissolved in chloroform and washed with aqueous sodium bicarbonate solution. The organic layer was dried over magnesium sulfate and evaporated. The residue was chromatographed on silica gel using a mixture of chloroform and methanol (95:5) to give 3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-2-(1-piperazinyl)-4-(2,4,6-trimethylphenylimino)pyrimidine (0.69 g).

1. temperatureThe mixture was refluxed for 3 hours
2. customThe mixture was evaporated
3. dissolutionthe residue was dissolved in chloroform
4. washwashed with aqueous sodium bicarbonate solution
5. dry with materialThe organic layer was dried over magnesium sulfate
6. customevaporated
7. customThe residue was chromatographed on silica gel using
8. additiona mixture of chloroform and methanol (95:5)