HuagongsheHuagongshe Chemistry Print Report · For research reference only
Octylamine → N-(n-octyl) 1-benzoyl-3-piperidinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Octylamine | HCID 8143 | — |
| Reactant | Ethyl 1-benzoyl-3-piperidinecarboxylate | HCID 3784394 | — |
| Reactant | N-benzoylnipecotoyl chloride | HCID 15718173 | — |
| Product | N-(n-octyl) 1-benzoyl-3-piperidinecarboxamide | HCID 70028584 | — |
Reaction Steps
The reaction was run in the same manner as ethyl 1-benzoyl-3-piperidinecarboxylate, starting with 1-benzoyl-3-piperidinecarbonyl chloride (219.0 mg; 0.87 mmol) and commercially available octylamine (144 μl; 0.87 mmol). The crude product was purified by chromatography on silica, eluting with 100% ethyl acetate, giving N-(n-octyl) 1-benzoyl-3-piperidinecarboxamide (207.5 mg) as a colorless waxy oil. MS m/z (positive ion) 345 (MH+; 100), 216 (30).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06664271B1 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-cb931919c702447e9f23b944378ed6ce |
| Source note | uspto-grants-2003_12 |