反应详情

1-(2-thiopheneacetyl)-3-piperidine carboxylic acid (1.3 g; 5.1 mmol) was dissolved in dry dichloromethane (35 ml) under a nitrogen atmosphere. Thionyl chloride (3 ml. 41.3 mmol) was added and the mixture was heated to reflux for approximately 1 hour. It was then cooled to ambient temperature and evaporated under reduced pressure, giving 1-(2-thiopheneacetyl)-3-piperidinecarbonyl chloride as a brownish oil. MS m/z (positive ion; run in CH3CN) 274 ([M+2]H+; 50), 272 (MH+; 100).

1. temperaturethe mixture was heated
2. temperatureto reflux for approximately 1 hour
3. customevaporated under reduced pressure