反应详情

The reaction was run in the same manner as ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate, starting with 3-(2-thienyl)acrylic acid (2.6 g; 16.9 mmol) and ethyl nipecotate (2.62 ml; 16.9 mmol). The crude product was purified by chromatography on silica, eluting with 40 to 100% ethyl acetate in hexane as a step gradient, giving ethyl 1-(3-(2-thienyl)acrylyl)-3-piperidinecarboxylate (1.74 g) as an off-white solid. MS m/z (positive ion) 316 (M+Na+; 25), 294 (MH+; 100).

1. customThe crude product was purified by chromatography on silica
2. washeluting with 40 to 100% ethyl acetate in hexane as a step gradient