HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiopheneacetyl chloride → Ethyl 1-(2-thiopheneacetyl)-6-methyl-3-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiopheneacetyl chloride | HCID 162362 | — |
| Reactant | Ethyl 1-benzoyl-3-piperidinecarboxylate | HCID 3784394 | — |
| Reactant | Ethyl 6-methylpiperidine-3-carboxylate | HCID 13658605 | — |
| Product | Ethyl 1-(2-thiopheneacetyl)-6-methyl-3-piperidinecarboxylate | HCID 18760296 | 59.8% |
Reaction Steps
The reaction was run in the same manner as ethyl 1-benzoyl-3-piperidinecarboxylate, starting with ethyl 6-methyl-3-piperidinecarboxylate (263.1 mg; 1.54 mmol) and 2-thiopheneacetyl chloride (190 μl; 1.54 mmol). The crude product was distilled at 210° C./0.1 torr, giving ethyl 1-(2-thiopheneacetyl)-6-methyl-3-piperidinecarboxylate (272.2 mg) as a light yellow oil. MS m/z (positive ion) 591(dimer+; 25) 296 (MH+; 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06664271B1 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-e2074a29c1044fc79c2e7d25282a6554 |
| Source note | uspto-grants-2003_12 |