Diisopropylethylamine → HCID 18760289, compound

Participants

Reaction Steps

This reaction was run in the same manner as ethyl 1-benzoyl-3-piperidinecarboxylate, starting with ethyl 5-methyl-3-piperidinecarboxylate (311 mg; 1.82 mmol), diisopropylethylamine (350 μl; 2.01 mmol), and thiopheneacetyl chloride (225 μl; 1.83 mmol). Crude product was purified by distillation at approximately 220° C./0.1 torr, giving ethyl 1-(2-thiopheneacetyl)-5-methyl-3-piperidinecarboxylate (398 mg) as a yellow oil. MS m/z (positive ion) 467 (25), 296 (MH+; 100).

Provenance & Evidence