反应详情

The mixture of 2-(5-methyl-2-phenyloxazol-4-yl)ethanol (2.03 g), 1,5-dibromopentane (4.09 ml), 50% NaOH (4.0 ml) and tributylammonium bromide (0.1 g) was stirred at room temperature overnight. The reaction mixture was diluted with ether, washed by water and an aqueous saturated solution of sodium chloride sucessively, dried over anhydrous magnesium sulfate and concentrated. The residue was purified with silica gel column chromatography (hexane:ethyl acetate=10:1→4:1) to obtain the title compound (3.45 g) having the following physical data.

1. washwashed by water
2. dry with materialan aqueous saturated solution of sodium chloride sucessively, dried over anhydrous magnesium sulfate
3. concentrationconcentrated
4. customThe residue was purified with silica gel column chromatography (hexane:ethyl acetate=10:1→4:1)