Chloroform → HCID 18760487, compound

HRID 432895Notes

Reaction equation

[CH2:1]([C:3]([NH2:12])([CH2:10][CH3:11])[CH2:4][NH:5][C:6]([CH3:9])([CH3:8])[CH3:7])[CH3:2].[CH3:13][C:14]([CH2:16][CH3:17])=O.[OH-:18].[Na+].[CH:20](Cl)(Cl)Cl>>[C:6]([N:5]1[CH2:4][C:3]([CH2:10][CH3:11])([CH2:1][CH3:2])[NH:12][C:14]([CH2:16][CH3:17])([CH3:20])[C:13]1=[O:18])([CH3:7])([CH3:9])[CH3:8]

Participants

Reactant 4

HCID 6212Chloroform

HCID 6569Methyl Ethyl Ketone

HCID 14798Sodium Hydroxide

HCID 18760498HCID 18760498, compound

Product 1

HCID 18760487HCID 18760487, compoundYield 64%

Procedure

In analogy to Example B21, 1,1-diethyl-2-t-butylaminoethylamin, methylethylketon, chloroform and NaOH are reacted to give the title compound (64%) as an yellow oil.

Sources & evidence

ORD record: ord-35911872bb6b4b8ea54f9cca8ee2779c
Source dataset: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06664353B2

Reaction notes

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