Phosphorus pentachloride → Nervonoyl chloride

Participants

Reaction Steps

Phosphorus pentachloride (0.123 mol, 25.6 g) was added gradually to a solution of nervonic acid (available from Aldrich Chemicals) (0.123 mol, 45.0 g) in dry ethyl ether (225 mL, C=200 g.L−1). The mixture was stirred at room temperature under nitrogen for 3 h and concentrated to dryness to yield z-15-tetracosenoyl chloride as pale yellow, fairly viscous oil.

Provenance & Evidence