1,1,1-Trimethoxybutane → HCID 22320428, compound

Participants

Reaction Steps

Using the general method of Example 1 Part D, N4-(5-chloropentyl)quinoline-3,4-diamine (˜20.4 mmol) was cyclized using trimethyl orthobutyrate (3.6 g, 24.5 mmol) in the presence of pyridine hydrochloride (˜0.1 g). The crude product was purified by column chromatography (silica gel eluting with 95/5 dichloromethane/methanol) to provide 3.9 g of 1-(5-chloropentyl)-2-propyl-1H-imidazo[4,5-c]quinoline as a light green solid.

Provenance & Evidence