HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → N-(4-chlorobutyl)-3-nitroquinolin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-[(3-Nitroquinolin-4-yl)amino]butan-1-ol | HCID 12106181 | — |
| Product | N-(4-chlorobutyl)-3-nitroquinolin-4-amine | HCID 22320535 | 99.6% |
Reaction Steps
Using the general method of Example 19 Part A, 4-[(3-nitroquinolin-4-yl)amino]butan-1-ol (120 g, 0.459 mol) was chlorinated with thionyl chloride (109 g, 0.919 mol) to provide 127.9 g of N-(4-chlorobutyl)-3-nitroquinolin-4-amine as a yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06667312B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-5af4e64726aa4dd9ae3d151a3de59e0a |
| Source note | uspto-grants-2003_12 |