HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl orthovalerate → HCID 22320468, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl orthovalerate | HCID 83755 | — |
| Reactant | HCID 69895270 | HCID 69895270 | — |
| Catalyst | Pyridinium chloride | HCID 10176127 | — |
| Product | HCID 22320468 | HCID 22320468 | 79.2% |
Reaction Steps
Using the general method of Example 1 Part D, N4-(4-chlorobutyl)quinoline-3,4-diamine (119.1 g, 0.48 mole) was cyclized using trimethyl orthovalerate (93 g, 0.57 mol) in the presence of pyridine hydrochloride (1.1 g, 0.0095 mol) to provide 120 g of 2-butyl-1-(4-chlorobutyl)-1H-imidazo[4,5-c]quinoline as an ivory powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06667312B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-cb2a6e77dec4477ea8221be047d49d19 |
| Source note | uspto-grants-2003_12 |