6-(Benzyloxy)pyridine-3-carboxylic acid → 3-Pyridinecarboxamide, N-(2-amino-2-oxoethyl)-6-(phenylmethoxy)-

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-benzyloxy-nicotinic acid (500 mg, 2.18 mmol), glycinamide HCI (265 mg, 2.4 mmol), 4-dimethylamino pyridine (133 mg; 1.09 mmol), N-(3-dimethylamino-propyl)-N′-ethylcarbodiimide HCl (460 mg; 2.4 mmol) and methylene chloride (10 ml) was stirred at 0° C. for 1 h then at r.t. overnight. The precipitate was filtered off and washed with methylene chloride and water. The title compound was obtained as a white solid (328 mg; 53%). MS: m/e=286.2 (M+H+).

Provenance & Evidence