反应详情

温度

0 °C

The 3-(4-cyanobenzyl)hydantoin derivative obtained in step F (about 14 mmol) was dissolved in 360 ml of a mixture of pyridine/acetic acid/water (2/1/1), cooled to 0° C. and treated with 25.1 g of sodium hypophosphite (monohydrate) and 4.17 g of moist Raney nickel. After stirring at 60° C. for 6 h, the solvents were removed in vacuo and the residue was taken up in ethyl acetate. The solvent was washed with 10% strength citric acid solution, saturated sodium bicarbonate solution and saturated sodium chloride solution and dried over magnesium sulfate. After filtration and concentration, the 3-(4-formylbenzyl)hydantoin derivative obtained was employed in the next step without further purification.

1. customthe solvents were removed in vacuo
2. washThe solvent was washed with 10% strength citric acid solution, saturated sodium bicarbonate solution and saturated sodium chloride solution
3. dry with materialdried over magnesium sulfate
4. filtrationAfter filtration and concentration