HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylethyl (3R)-3-aminobutanoate → (R)-3-((S)-2-(4,4-Dimethyl-3-(4-styrylbenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-methylpropionic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylethyl (3R)-3-aminobutanoate | HCID 2733826 | — |
| Reactant | 4-Chloromethylstilbene | HCID 3530988 | — |
| Reactant | tert-butyl (S)-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetate | HCID 86759309 | — |
| Product | (R)-3-((S)-2-(4,4-Dimethyl-3-(4-styrylbenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-methylpropionic Acid | HCID 68420215 | — |
Reaction Steps
The compound was prepared according to the general preparation processes, steps A, B, D, E and J. In step D, tert-butyl (S)-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetate was alkylated with 4-chloromethylstilbene. In step J, tert-butyl (R)-3-amino-3-methylpropionate was employed as an amino compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06667334B1 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-0b772484ae9d4614a9da21c0f6167bbe |
| Source note | uspto-grants-2003_12 |