HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylethyl (3R)-3-aminobutanoate → (R)-3-((S)-2-(3-(4-Benzyloxybenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-methylpropionic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylethyl (3R)-3-aminobutanoate | HCID 2733826 | — |
| Reactant | 1-(Benzyloxy)-4-(bromomethyl)benzene | HCID 10492756 | — |
| Reactant | tert-butyl (S)-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetate | HCID 86759309 | — |
| Product | (R)-3-((S)-2-(3-(4-Benzyloxybenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-methylpropionic Acid | HCID 9892992 | — |
Reaction Steps
The compound was prepared according to the general preparation processes, steps A, B, D, E and J. In step D, tert-butyl (S)-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetate was alkylated with 4-benzyloxybenzyl bromide. In step J, the amino compound employed was tert-butyl (R)-3-amino-3-methylpropionate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06667334B1 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-08d1a1ccf734432aa2baf628a7c27924 |
| Source note | uspto-grants-2003_12 |