HuagongsheHuagongshe Chemistry Print Report · For research reference only
Purine → 2-(7-Amino-1,2,3-triazolo[4,5-d]pyrimidin-3-ylmethyl)-5-methyl-3-o-tolyl-3h-quinazolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Purine | HCID 1044 | — |
| Reactant | IC 87114 | HCID 9908783 | — |
| Product | 2-(7-Amino-1,2,3-triazolo[4,5-d]pyrimidin-3-ylmethyl)-5-methyl-3-o-tolyl-3h-quinazolin-4-one | HCID 10178984 | — |
Reaction Steps
1H NMR (300 MHz, d6-DMSO) δ: 8.43 (br s, 1H), 8.19 (s, 1H), 8.10 (br s, 1H), 7.62 (t, J=7.8 Hz, 1H), 7.49-7.28 (m, 5H), 7.22 (d, J=8.1 Hz, 1H), 5.49 (d, J=17.0 Hz, 1H), 5.19 (d, J=17.0 Hz, 1H), 2.73 (s, 3H), 2.11 (s, 3H). Alkylation at purine N7 determined by similarity to nmr spectrum of D-030. LRMS (ES pos.) m/z=399 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06667300B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-007c08e46ea34bedbf27610bfe026a07 |
| Source note | uspto-grants-2003_12 |