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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 433351Generated: October 29, 2026

2-Chloropropionic acid → N-(3,5-difluorophenyl)alanine

https://huagongshe.com/reaction/433351

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloropropionic acidHCID 11734—
Reactant3,5-DifluoroanilineHCID 96595—
ProductN-(3,5-difluorophenyl)alanineHCID 53936901—

Reaction Steps

Using the procedure set forth in U.S. Pat. No. 3,598,859 and Example Q above, N-(3,5-difluorophenyl)alanine was prepared using 3,5-difluoroaniline (Aldrich) and 2-chloropropionic acid (Aldrich).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06667305B1
Source datasetuspto-grants-2003_12
ORD IDord-4461110f497b4db0bc14f12d608fa237
Source noteuspto-grants-2003_12