1-Amino-1,2,3,4-tetrahydronaphthalen-2-ol → 1-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)-amino-1,2,3, 4tetrahydro-2-naphthol

HRID 433356Notes

Reaction equation

HRID 433356 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:18][CH:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][CH:20]1[OH:29]>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([C:19]2([NH2:18])[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:22][CH2:21][CH:20]2[OH:29])=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

3

Reactant 2

HCID 44601871-Amino-1,2,3,4-tetrahydronaphthalen-2-olHCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid

Product 1

HCID 545402011-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)-amino-1,2,3, 4tetrahydro-2-naphthol

Procedure

Following General Procedure C and using using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 1-amino-1,2,3,4-tetrahydro-2-naphthol, the title compound was prepared.

Sources & evidence

ORD record
ord-6ac7cf29da01470d9d6a8ae3c95195f2
Source dataset
uspto-grants-2003_12
Patent number
US06667305B1

Reaction notes

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