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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 433409Generated: October 28, 2026

Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)- → HCID 131723824, compound

https://huagongshe.com/reaction/433409

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)-HCID 6951479—
ReactantHCID 23552793HCID 23552793—
SolventChloroform methanolHCID 21584188—
ProductHCID 131723824HCID 131723824—

Reaction Steps

Following General Procedure D and using (S)-3,5-difluoromandelic acid (Example L) and 5-(L-alaninyl)-amino-10-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one hydrochloride (Example 7-Q), the title compound was prepared. The reaction was monitored by tlc (Rf=0.4. 10% MeOH/CHCl3) and product was purified by chromatography (silica. 2.5% MeOH/CHCl3).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06667305B1
Source datasetuspto-grants-2003_12
ORD IDord-e9f7ad06bab34c8495fb6a011b761867
Source noteuspto-grants-2003_12