反应详情

A mixture of D7 (761 mg, 1.58 mmol), 2M NaOH solution (6 ml) and 1,4-dioxane (6 ml) was stirred at room temperature for 2 h. The solvents were removed and the residue dissolved in water and the pH adjusted to 4 with 2M HCl. The product was extracted with EtOAc and the combined extracts were dried and concentrated. The product was refluxed in toluene (˜20 ml) for 2 h and the solvent was evaporated to give the title compound as a yellow foam (505 mg). MS (ES): MH+ 383, (M−H)− 381.

1. customThe solvents were removed
2. dissolutionthe residue dissolved in water
3. extractionThe product was extracted with EtOAc
4. customthe combined extracts were dried
5. concentrationconcentrated
6. temperatureThe product was refluxed in toluene (˜20 ml) for 2 h
7. customthe solvent was evaporated