3,5-Difluorophenylacetic acid → HCID 22984121, compound

HRID 433425Notes

Reaction equation

HRID 433425 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:13][C@H:14]([C:18]([NH:20][CH:21]1[N:27]=[C:26]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:25]2[CH:34]=[CH:35][CH:36]=[CH:37][C:24]=2[N:23]([CH3:38])[C:22]1=[O:39])=[O:19])[CH:15]([CH3:17])[CH3:16]>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:13][C@H:14]([C:18]([NH:20][CH:21]2[N:27]=[C:26]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]=3[N:23]([CH3:38])[C:22]2=[O:39])=[O:19])[CH:15]([CH3:17])[CH3:16])=[O:12])[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 23552779HCID 23552779, compound

Product 1

HCID 22984121HCID 22984121, compound

Procedure

Following General Procedure D above using 3,5-difluorophenylacetic acid (Oakwood Products, Inc.) and 3-(L-valinyl)amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one (Example 8-Y), the title compound was prepared as a solid (mp.=228-229° C.). The product was purified by slurrying in ether/hexanes (80:20).

Workup

  1. customThe product was purified

Sources & evidence

ORD record
ord-31a86da602264fb198542e805da97e7c
Source dataset
uspto-grants-2003_12
Patent number
US06667305B1

Reaction notes

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