huagongshe.com
HRID433433

反应详情

EQUATION

反应方程式

HRID 433433 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)C(O)c1cc(F)cc(F)c1
HCID588648

3,5-Difluoromandelic acid

C8H6F2O3

结构：C[C@H](N)C(=O)C1(N)C(=O)N(C)c2ccccc2N(C)C1=O.Cl
HCID69033234

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H](NC(=O)C(O)c1cc(F)cc(F)c1)C(=O)NC1C(=O)N(C)c2ccccc2N(C)C1=O
HCID22984128

未命名化合物

PROCEDURE

实验过程

Following General Procedure I above using 3,5-difluoromandelic acid (Lancaster) and the product from Example 8-R, the title compound was prepared as an amorphous white solid. Purification was by L.C. 2000 eluting with straight EtOAc then flash chromatography eluting with CH2Cl2/Acetone (4:1 gradient to 3:1). Rf=0.39 and 0.34 (EtOAc).

WORKUP

后处理

  1. customPurification
  2. wash2000 eluting with straight EtOAc then flash chromatography eluting with CH2Cl2/Acetone (4:1 gradient to 3:1)