反应详情

温度

120 °C

The mixture of 4-chloro-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine (2.0 g) and 2,4,6-trimethylaniline (5.3 ml) was stirred at 120° C. for an hour. After cooled, the mixture was triturated with ethyl acetate. The precipitates were collected, and dissolved in chloroform. The solution was washed with aqueous sodium bicarbonate solution, dried over magnesium sulfate, and evaporated to give 6-(3,4-dimethoxyphenyl)-2-methyl-4-(2,4,6-trimethylphenylamino)pyrimidine (2.39 g).

1. temperatureAfter cooled
2. customthe mixture was triturated with ethyl acetate
3. customThe precipitates were collected
4. dissolutiondissolved in chloroform
5. washThe solution was washed with aqueous sodium bicarbonate solution
6. dry with materialdried over magnesium sulfate
7. customevaporated