HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Phenylbutyric Acid → N-(4phenylbutanoyl)-L-alanine iso-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Phenylbutyric Acid | HCID 4775 | — |
| Reactant | 2-Methylpropyl (2S)-2-aminopropanoate hydrochloride | HCID 86584981 | — |
| Product | N-(4phenylbutanoyl)-L-alanine iso-butyl ester | HCID 15481769 | — |
Reaction Steps
Following General Procedure BB and using 4-phenylbutanoic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06667305B1 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-040fa4fee15c4ebaa7fcece3434431a7 |
| Source note | uspto-grants-2003_12 |