3,4-Dichlorophenylacetic acid → 2-[(3,4Dichlorophenyl)acetamido]butyric acid isobutyl ester

HRID 433513Notes

Reaction equation

HRID 433513 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[NH2:13][CH:14]([CH2:22][CH3:23])[C:15]([O:17][CH2:18][CH:19]([CH3:21])[CH3:20])=[O:16]>>[CH2:18]([O:17][C:15](=[O:16])[CH:14]([NH:13][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)[CH2:22][CH3:23])[CH:19]([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 798743,4-Dichlorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 543898612-[(3,4Dichlorophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure BI above and using 3,4-dichlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above) the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Sources & evidence

ORD record
ord-69dad2f1fa8b418aa46b03d31ad86f66
Source dataset
uspto-grants-2003_12
Patent number
US06667305B1

Reaction notes

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