(4-Nitrophenyl)acetic acid → 2-[(4Nitrophenyl)acetamido]butyric acid iso-butyl ester

HRID 433515Notes

Reaction equation

HRID 433515 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([OH:13])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH2:14][CH:15]([CH2:23][CH3:24])[C:16]([O:18][CH2:19][CH:20]([CH3:22])[CH3:21])=[O:17]>>[CH2:19]([O:18][C:16](=[O:17])[CH:15]([NH:14][C:11](=[O:13])[CH2:10][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=1)[CH2:23][CH3:24])[CH:20]([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 4661(4-Nitrophenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 537955052-[(4Nitrophenyl)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure BI above and using 4-nitrophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-5cf0f22c9498439f8823fb8bed58aec7
Source dataset
uspto-grants-2003_12
Patent number
US06667305B1

Reaction notes

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