3-Nitrophenylacetic acid → 2-[(3Nitrophenyl)acetamido]butyric acid iso-butyl ester

HRID 433518Notes

Reaction equation

HRID 433518 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([OH:13])=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[NH2:14][CH:15]([CH2:23][CH3:24])[C:16]([O:18][CH2:19][CH:20]([CH3:22])[CH3:21])=[O:17]>>[CH2:19]([O:18][C:16](=[O:17])[CH:15]([NH:14][C:11](=[O:13])[CH2:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[CH2:23][CH3:24])[CH:20]([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 158763-Nitrophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 539659122-[(3Nitrophenyl)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure BI above and using 3-nitrophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-4619ec08e41f43d29e27392ab0249bb7
Source dataset
uspto-grants-2003_12
Patent number
US06667305B1

Reaction notes

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