4-Amino-1-Boc-piperidine → 1,1-Dimethylethyl 4-[(3-cyano-4-fluorophenyl)amino]-1-piperidinecarboxylate

HRID 43352Notes

Reaction equation

HRID 43352 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[C:7]#[N:8].[NH2:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14][CH2:13]1>>[C:7]([C:6]1[CH:9]=[C:2]([NH:11][CH:12]2[CH2:13][CH2:14][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:16][CH2:17]2)[CH:3]=[CH:4][C:5]=1[F:10])#[N:8]

Participants

3

Reactant 2

HCID 12682914-Amino-1-Boc-piperidineHCID 27249005-Bromo-2-fluorobenzonitrile

Product 1

HCID 671280881,1-Dimethylethyl 4-[(3-cyano-4-fluorophenyl)amino]-1-piperidinecarboxylate

Procedure

The title compound was prepared from 5-bromo-2-fluorobenzonitrile and 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate using a method similar to that described for D10a.

Sources & evidence

ORD record
ord-2c4dc3952e974ba3ba1a101c341b54fb
Source dataset
uspto-grants-2013_09
Patent number
US08536182B2

Reaction notes

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