2-Naphthaleneacetic acid → 2-[(2-naphthyl)acetamido]butyric Acid Iso-butyl Ester

HRID 433520Notes

Reaction equation

HRID 433520 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C:12]([OH:14])=O.[NH2:15][CH:16]([CH2:24][CH3:25])[C:17]([O:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[O:18]>>[CH2:20]([O:19][C:17](=[O:18])[CH:16]([NH:15][C:12](=[O:14])[CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[CH2:24][CH3:25])[CH:21]([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 113932-Naphthaleneacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 536358212-[(2-naphthyl)acetamido]butyric Acid Iso-butyl Ester

Procedure

Following General Procedure BI above and using 2-naphthylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-d8bb8048b3214bc4aa506677a07f6838
Source dataset
uspto-grants-2003_12
Patent number
US06667305B1

Reaction notes

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