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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 433540Generated: October 25, 2026

3,5-Difluorophenylacetic acid → N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester

https://huagongshe.com/reaction/433540

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Difluorophenylacetic acidHCID 145424—
Reactant2-methylpropyl (2S)-2-aminopropanoateHCID 13743556—
ProductN-[(3,5-difluorophenyl)acetyl]alanine iso-butyl esterHCID 22894975—

Reaction Steps

Following General Procedure BI above, and using 3,5-difluorophenylacetic acid (Aldrich) and alanine iso-Butyl Ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06667305B1
Source datasetuspto-grants-2003_12
ORD IDord-9ce02f93550240f3aae07095c15bee15
Source noteuspto-grants-2003_12