3-Chlorophenylacetic acid → N-[(3-Chlorophenyl)acetyl]alanine Isobutyl Ester

HRID 433546Notes

Reaction equation

HRID 433546 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH2:19])[CH:13]([CH3:15])[CH3:14]>>[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH:19][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)[CH:13]([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 158793-Chlorophenylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 54342799N-[(3-Chlorophenyl)acetyl]alanine Isobutyl Ester

Procedure

Following General Procedure BG above and using 3-chlorophenylacetic acid (Aldrich) and alanine iso-Butyl Ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel.

Sources & evidence

ORD record
ord-2717936152eb4a0a9aecca496e02d8d6
Source dataset
uspto-grants-2003_12
Patent number
US06667305B1

Reaction notes

Loading…