HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-[1-(4-Chloro-3-methyl-phenyl)-1H-imidazol-4-yl-methyl]-4,5,6,7-tetrahydro-1H-benzoimidazole-, Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4,5,6,7-Tetrahydro-1H-benzimidazole | HCID 304263 | — |
| Reactant | 1-(4-Chloro-3-methylphenyl)-1H-imidazole-4-methanol | HCID 23445048 | — |
| Product | 1-[1-(4-Chloro-3-methyl-phenyl)-1H-imidazol-4-yl-methyl]-4,5,6,7-tetrahydro-1H-benzoimidazole-, Hydrochloride | HCID 131724046 | — |
Reaction Steps
[1-(4-Chloro-3-methyl-phenyl)-1H-imidazol-4-yl]-methanol was treated first with thionylchloride, then with the reaction mixture of sodium hydride and 4,5,6,7-tetrahydro-benzimidazole. After extractive workup and chromatography the title compound was obtained as the free base. It was converted into its white hydrochloride salt. Mp. >250° C. (MeOH/Et2O); MS: m/e=326 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06667335B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-97482add16ad48bbb17683586257f22f |
| Source note | uspto-grants-2003_12 |