2-Ethylimidazole → HCID 23444976, compound

HRID 433567Notes

Reaction equation

Cl.[Cl:2][CH2:3][C:4]1[CH:5]=[N:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([Cl:17])[CH:11]=2)[CH:9]=1.[CH2:18]([C:20]1[NH:21][CH:22]=[CH:23][N:24]=1)[CH3:19]>>[ClH:2].[Cl:17][C:12]1[CH:11]=[C:10]([C:8]2[CH:7]=[N:6][CH:5]=[C:4]([CH2:3][N:21]3[CH:22]=[CH:23][N:24]=[C:20]3[CH2:18][CH3:19])[CH:9]=2)[CH:15]=[CH:14][C:13]=1[Cl:16]

Participants

Reactant 2

HCID 661302-Ethylimidazole

HCID 23445085HCID 23445085, compound

Product 1

HCID 23444976HCID 23444976, compound

Procedure

The title compound, MS: m/e=332.2 (M+H+) was obtained as an orange solid (49% yield) by the reaction of 3-chloromethyl-5-(3,4-dichloro-phenyl)-pyridine hydrochloride (1:1) with 2-ethylimidazole, using sodium hydride and triethylamine as base followed by formation of the hydrochloride salt.

Sources & evidence

ORD record: ord-bff93e23e82244e6bee8fde1f0387323
Source dataset: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06667335B2

Reaction notes

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