Thionyl Chloride → HCID 23445085, compound

HRID 433595Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([CH2:15]O)[CH:12]=[N:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].S(Cl)([Cl:19])=O>>[ClH:1].[Cl:19][CH2:15][C:11]1[CH:12]=[N:13][CH:14]=[C:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[CH:10]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 23445111HCID 23445111, compound

Product 1

HCID 23445085HCID 23445085, compoundYield 98%

Procedure

A solution of [5-(3,4-dichloro-phenyl)-pyridine-3-yl]-methanol (470 mg, 1.9 mmol) in thionyl chloride (4.9 ml) was stirred at 20° C. for 15 h. Evaporation of the thionyl chloride and drying under high vacuum at 50° C. for 2 h afforded the title compound (558 mg, 98%) as a light yellow solid. MS: m/e=271.0 (M+).

Workup

customEvaporation of the thionyl chloride
customdrying under high vacuum at 50° C. for 2 h

Sources & evidence

ORD record: ord-1ef0b0d2298048309857acd5839bee45
Source dataset: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06667335B2

Reaction notes

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