Diiodomethane → HCID 23445035, compound

Participants

Reaction Conditions

Reaction Steps

Under an Ar atmosphere, a mixture of [1-(3-vinyl-phenyl)-1H-imidazol-4-yl]-methanol (0.10 g, 0.5 mmol) in toluene (20 ml) was successively treated with diethylzinc (3.8 ml of a 1.1 M solution in hexane, 4.2 mmol) and diiodomethane (6.6 g, 25 mmol). The resulting mixture was stirred at 20° C. for 12 h. The preciptate was filtered and stirred for 30 min with AcOEt and saturated aqueous NH4Cl solution. The organic phase was separated, dried (Na2SO4) and concentrated to yield the title compound as a yellow oil (0.10 g, 93%). MS: m/e=215 (M+H+).

Provenance & Evidence