HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Ethyl 1-(5-chloro-2-pyridinyl)-1H-imidazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 2-Amino-5-chloropyridine | HCID 66174 | — |
| Reactant | Ethyl nitroacetate | HCID 69379 | — |
| Catalyst | Iron | HCID 23925 | — |
| Product | Ethyl 1-(5-chloro-2-pyridinyl)-1H-imidazole-4-carboxylate | HCID 53752991 | — |
Reaction Steps
Following the general method described in example 384, 2-amino-5-chloropyridine was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid. After workup and chromatography the title compound was obtained as a beige crystalline solid. Mp. 163-164° C. (AcOEt), MS: m/e=252 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06667335B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-d6f0f3bc6ffc4872a3395895ca6eea0e |
| Source note | uspto-grants-2003_12 |