Diisobutylaluminumhydride → HCID 23445089, compound

HRID 433636Notes

Reaction equation

HRID 433636 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][N:12]=2)[CH:10]=1)=O)C.[H-].C([Al+]CC(C)C)C(C)C>>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([N:9]2[CH:10]=[C:6]([CH2:4][OH:3])[N:7]=[CH:8]2)=[N:12][CH:13]=1

Participants

3

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 53752991Ethyl 1-(5-chloro-2-pyridinyl)-1H-imidazole-4-carboxylate

Product 1

HCID 23445089HCID 23445089, compound

Procedure

Following the general method described in example 388, 1-(5-chloro-pyridin-2-yl)-1H-imidazole-4-carboxylic acid ethyl ester was reacted with diisobutylaluminum hydride. After hydrolytic workup and chromatography the title compound was obtained as a light brown crystalline solid. Mp. 82-87° C. (AcOEt/Et2O), MS: m/e=210 (M+H+).

Sources & evidence

ORD record
ord-bde480d7c53e418bb93d8442670beaa7
Source dataset
uspto-grants-2003_12
Patent number
US06667335B2

Reaction notes

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