Diisobutylaluminumhydride → HCID 23445131, compound

HRID 433642Notes

Reaction equation

HRID 433642 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:11]2[CH:12]=[C:13]3[C:18](=[CH:19][CH:20]=2)[N:17]=[CH:16][CH:15]=[CH:14]3)[CH:10]=1)=O)C.[H-].C([Al+]CC(C)C)C(C)C>>[N:17]1[C:18]2[C:13](=[CH:12][C:11]([N:9]3[CH:10]=[C:6]([CH2:4][OH:3])[N:7]=[CH:8]3)=[CH:20][CH:19]=2)[CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 69042755HCID 69042755, compound

Product 1

HCID 23445131HCID 23445131, compound

Procedure

Following the general method described in example 388, 1-quinolin-6-yl-1H-imidazole-4-carboxylic acid ethyl ester was reacted with diisobutylaluminum hydride. After hydrolytic workup and chromatography the title compound was obtained as a light brown crystalline solid. Mp. 183-187° C. (AcOEt/hexane), MS: m/e=226 (M+H+).

Sources & evidence

ORD record
ord-df57793a1df54a9abb5a39ec2fbf0052
Source dataset
uspto-grants-2003_12
Patent number
US06667335B2

Reaction notes

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