Diisobutylaluminumhydride → HCID 23445077, compound

HRID 433644Notes

Reaction equation

HRID 433644 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:11]2[CH:12]=[CH:13][CH:14]=[C:15]3[C:20]=2[N:19]=[CH:18][CH:17]=[CH:16]3)[CH:10]=1)=O)C.[H-].C([Al+]CC(C)C)C(C)C>>[N:19]1[C:20]2[C:15](=[CH:14][CH:13]=[CH:12][C:11]=2[N:9]2[CH:10]=[C:6]([CH2:4][OH:3])[N:7]=[CH:8]2)[CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 69043488HCID 69043488, compound

Product 1

HCID 23445077HCID 23445077, compound

Procedure

Following the general method described in example 388, 1-quinolin-8-yl-1H-imidazole-4-carboxylic acid ethyl ester was reacted with diisobutylaluminum hydride. After hydrolytic workup and chromatography the title compound was obtained as a light brown crystalline solid. Mp. 168-170° C. (Et2O), MS: m/e=225 (M+).

Sources & evidence

ORD record
ord-4d655f9da78140caa5551bc38ae540e1
Source dataset
uspto-grants-2003_12
Patent number
US06667335B2

Reaction notes

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