2,6-Dichlorobenzoyl chloride → HCID 20610316, compound

HRID 433680Notes

Reaction equation

HRID 433680 reaction equation
Cl.[C:2]([O:6][C:7]([N:9]1[CH2:13][CH2:12][CH2:11][CH:10]1[C:14]1[CH:18]=[C:17]([CH2:19][CH:20]([NH2:26])[C:21]([O:23][CH2:24][CH3:25])=[O:22])[O:16][N:15]=1)=[O:8])([CH3:5])([CH3:4])[CH3:3].[Cl:27][C:28]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[C:29]=1[C:30](Cl)=[O:31]>>[C:2]([O:6][C:7]([N:9]1[CH2:13][CH2:12][CH2:11][CH:10]1[C:14]1[CH:18]=[C:17]([CH2:19][CH:20]([NH:26][C:30](=[O:31])[C:29]2[C:28]([Cl:27])=[CH:36][CH:35]=[CH:34][C:33]=2[Cl:37])[C:21]([O:23][CH2:24][CH3:25])=[O:22])[O:16][N:15]=1)=[O:8])([CH3:4])([CH3:5])[CH3:3]

Participants

3

Reactant 2

HCID 783922,6-Dichlorobenzoyl chlorideHCID 131724266HCID 131724266, compound

Product 1

HCID 20610316HCID 20610316, compound

Procedure

The title compound was prepared from 2-[5-(2-amino-2-ethoxycarbonyl-ethyl)-isoxazol-3-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester hydrocloride and 2,6-dichlorobenzoylchloride in the manner described in example 3B. MS (Ci) m/z 525.9 (M+1), 425.9 (M−99).

Sources & evidence

ORD record
ord-f7f04a75802a4df8b28521e0df861df3
Source dataset
uspto-grants-2003_12
Patent number
US06667331B2

Reaction notes

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